Need Help Reducing ACOS for Supplement Ads on Amazon

I’ve been running ads for my supplement product on Amazon for the last 2 months. My current ACOS is stuck around 45%, and I’m aiming to bring it down to 20%.

I’m running both keyword-targeted and ASIN-targeted campaigns. ACOS across them ranges between 10% to 75%. I’ve already paused all keywords and ASINs with ACOS over 80%.

Most of my sales are coming from keywords and ASINs that have 40-50% ACOS, so pausing those would hurt sales.

Any tips on how to optimize and bring down the ACOS while still maintaining sales? Would appreciate any advice or strategies that worked for you.